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EC 2.7.8.27 Details

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EC number

2.7.8.27

Accepted name

sphingomyelin synthase

Reaction

a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol

Other name(s)

SM synthase, SMS1, SMS2

Systematic name

ceramide:phosphatidylcholine cholinephosphotransferase

CAS registry number

58703-97-2

Comment

The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2].

History

created 2006

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.23.1 With NADH or NADPH as donor

1.23.5 With a quinone or similar compound as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.8 Transferases for other substituted phosphate groups

2.7.8.1 ethanolaminephosphotransferase

2.7.8.2 diacylglycerol cholinephosphotransferase

2.7.8.3 ceramide cholinephosphotransferase

2.7.8.4 serine-phosphoethanolamine synthase

2.7.8.5 CDP-diacylglycerol—glycerol-3-phosphate 1-phosphatidyltransferase

2.7.8.6 undecaprenyl-phosphate galactose phosphotransferase

2.7.8.7 holo-[acyl-carrier-protein] synthase

2.7.8.8 CDP-diacylglycerol—serine O-phosphatidyltransferase

2.7.8.9 phosphomannan mannosephosphotransferase

2.7.8.10 sphingosine cholinephosphotransferase

2.7.8.11 CDP-diacylglycerol—inositol 3-phosphatidyltransferase

2.7.8.12 teichoic acid poly(glycerol phosphate) polymerase

2.7.8.13 phospho-N-acetylmuramoyl-pentapeptide-transferase

2.7.8.14 CDP-ribitol ribitolphosphotransferase

2.7.8.15 UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase

2.7.8.16 created 1983, deleted 1986

2.7.8.17 UDP-N-acetylglucosamine—lysosomal-enzyme N-acetylglucosaminephosphotransferase

2.7.8.18 UDP-galactose—UDP-N-acetylglucosamine galactose phosphotransferase

2.7.8.19 UDP-glucose—glycoprotein glucose phosphotransferase

2.7.8.20 phosphatidylglycerol—membrane-oligosaccharide glycerophosphotransferase

2.7.8.21 membrane-oligosaccharide glycerophosphotransferase

2.7.8.22 1-alkenyl-2-acylglycerol choline phosphotransferase

2.7.8.23 carboxyvinyl-carboxyphosphonate phosphorylmutase

2.7.8.24 phosphatidylcholine synthase

2.7.8.25 triphosphoribosyl-dephospho-CoA synthase

2.7.8.26 adenosylcobinamide-GDP ribazoletransferase

2.7.8.27 sphingomyelin synthase

2.7.8.28 2-phospho-L-lactate transferase

2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase

2.7.8.30 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

2.7.8.31 undecaprenyl-phosphate glucose phosphotransferase

2.7.8.32 3-O-α-D-mannopyranosyl-α-D-mannopyranose xylosylphosphotransferase

2.7.8.33 UDP-N-acetylglucosamine—undecaprenyl-phosphate N-acetylglucosaminephosphotransferase

2.7.8.34 CDP-L-myo-inositol myo-inositolphosphotransferase

2.7.8.35 UDP-N-acetylglucosamine—decaprenyl-phosphate N-acetylglucosaminephosphotransferase

2.7.8.36 undecaprenyl phosphate N,N′-diacetylbacillosamine 1-phosphate transferase

2.7.8.37 α-D-ribose 1-methylphosphonate 5-triphosphate synthase

2.7.8.38 archaetidylserine synthase

2.7.8.39 archaetidylinositol phosphate synthase

2.7.8.40 UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase

2.7.8.41 cardiolipin synthase (CMP-forming)

2.7.8.42 Kdo₂-lipid A phosphoethanolamine 7′′-transferase

2.7.8.43 lipid A phosphoethanolamine transferase

2.7.8.44 teichoic acid glycerol-phosphate primase

2.7.8.45 teichoic acid glycerol-phosphate transferase

2.7.8.46 teichoic acid ribitol-phosphate primase

2.7.8.47 teichoic acid ribitol-phosphate polymerase

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.11 Protein-serine/threonine kinases

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)