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EC 1.16.1.5 Details

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EC number

1.16.1.5

Accepted name

aquacobalamin reductase (NADPH)

Reaction

2 cob(II)alamin + NADP⁺ + 2 H₂O = 2 aquacob(III)alamin + NADPH + H⁺

Other name(s)

aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase, NADPH-linked aquacobalamin reductase, NADPH₂:aquacob(III)alamin oxidoreductase

Systematic name

cob(II)alamin:NADP⁺ oxidoreductase

CAS registry number

110777-32-7

Comment

A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.

History

created 1989 as EC 1.6.99.11, transferred 2002 to EC 1.16.1.5, modified 2020, deleted 2020

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.2 With a cytochrome as acceptor

1.8.3 With oxygen as acceptor

1.8.4 With a disulfide as acceptor

1.8.5 With a quinone or similar compound as acceptor

1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

1.8.7 With an iron-sulfur protein as acceptor

1.8.98 With other, known, physiological acceptors

1.8.99 With unknown physiological acceptors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.7.1 created 1972, deleted 1978

1.12.7.2 ferredoxin hydrogenase

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.16.1 With NAD⁺ or NADP⁺ as acceptor

1.16.1.1 mercury(II) reductase

1.16.1.2 diferric-transferrin reductase

1.16.1.3 aquacobalamin reductase

1.16.1.4 cob(II)alamin reductase

1.16.1.5 aquacobalamin reductase (NADPH)

1.16.1.6 cyanocobalamin reductase

1.16.1.7 ferric-chelate reductase (NADH)

1.16.1.8 [methionine synthase] reductase

1.16.1.9 ferric-chelate reductase (NADPH)

1.16.1.10 ferric-chelate reductase [NAD(P)H]

1.16.3 With oxygen as acceptor

1.16.5 With a quinone or similar compound as acceptor

1.16.8 With a flavin as acceptor

1.16.9 With a copper protein as acceptor

1.16.98 With other, known, physiological acceptors

1.16.99 With unknown physiological acceptors

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)