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EC 1.11.2.6 Details

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EC number

1.11.2.6

Accepted name

L-tyrosine peroxygenase

Reaction

L-tyrosine + H₂O₂ = L-dopa + H₂O

Systematic name

L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)

Comment

The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.

History

created 2020

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.3.1 NAD(P)H oxidase (H₂O₂-forming)

1.6.3.2 NAD(P)H oxidase (H₂O-forming)

1.6.3.3 NADH oxidase (H₂O₂-forming)

1.6.3.4 NADH oxidase (H₂O-forming)

1.6.3.5 renalase

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.4.1 created 1961, deleted 2002

1.6.4.2 created 1961, modified 1989, deleted 2002

1.6.4.3 created 1961, modified 1976, deleted 1983

1.6.4.4 created 1965, deleted 2002

1.6.4.5 created 1972, deleted 2002

1.6.4.6 created 1972, deleted 2002

1.6.4.7 created 1978, deleted 2002

1.6.4.8 created 1989, deleted 2002

1.6.4.9 created 1992, deleted 2002

1.6.4.10 created 1992, deleted 2002

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.2 Peroxygenases

1.11.2.1 unspecific peroxygenase

1.11.2.2 myeloperoxidase

1.11.2.3 plant seed peroxygenase

1.11.2.4 fatty-acid peroxygenase

1.11.2.5 3-methyl-L-tyrosine peroxygenase

1.11.2.6 L-tyrosine peroxygenase

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)