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EC 1.11.1.20 Details
show Brenda entryEC number
1.11.1.20
Accepted name
prostamide/prostaglandin F2α synthase
Reaction
thioredoxin + (5Z,9α,11α,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate = thioredoxin disulfide + (5Z,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
Other name(s)
prostamide/PGF synthase,
prostamide F synthase,
prostamide/prostaglandin F synthase,
tPGF synthase
Systematic name
thioredoxin:(5Z,9α,11α,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase
Comment
The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2α. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
History
created 2011
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.7.1 created 1972, deleted 1978 1.6.7.2 created 1972, deleted 1978 1.6.7.3 created 1978, deleted 1978
