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EC 1.6.2.4 Details
EC number
1.6.2.4
Accepted name
NADPH—hemoprotein reductase
Reaction
NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
Other name(s)
CPR,
FAD-cytochrome c reductase,
NADP-cytochrome c reductase,
NADP-cytochrome reductase,
NADPH-dependent cytochrome c reductase,
NADPH:P-450 reductase,
NADPH:ferrihemoprotein oxidoreductase,
NADPH—cytochrome P-450 oxidoreductase,
NADPH-cytochrome c oxidoreductase,
NADPH-cytochrome c reductase,
NADPH—cytochrome p-450 reductase,
NADPH-ferricytochrome c oxidoreductase,
NADPH-ferrihemoprotein reductase,
TPNH2 cytochrome c reductase,
TPNH-cytochrome c reductase,
aldehyde reductase (NADPH-dependent),
cytochrome P-450 reductase,
cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent),
dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase,
ferrihemoprotein P-450 reductase,
reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase,
reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
Systematic name
NADPH:hemoprotein oxidoreductase
CAS registry number
9023-03-4
Comment
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases (e.g. EC 1.14.14.1, unspecific monooxygenase) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. It also reduces cytochrome b5 and cytochrome c. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
History
created 1972, modified 2003
EC Tree
1.6.2.1 created 1961, deleted 1965
1.6.2.3 created 1972, deleted 1965