EC Explorer

[browse EC tree] - [search]

EC 1.6.5.12 Details

show Brenda entry

EC number

1.6.5.12

Accepted name

demethylphylloquinone reductase

Reaction

demethylphylloquinone + NADPH + H⁺ = demethylphylloquinol + NADP⁺

Other name(s)

ndbB (gene name), NDC1 (gene name), demethylphylloquinone:NADPH oxidoreductase

Systematic name

NADPH:demethylphylloquinone oxidoreductase

Comment

The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K₁), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.

History

created 2015

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.2.1 created 1961, deleted 1965

1.6.2.2 cytochrome-b₅ reductase

1.6.2.3 created 1972, deleted 1965

1.6.2.4 NADPH—hemoprotein reductase

1.6.2.5 NADPH—cytochrome-c₂ reductase

1.6.2.6 leghemoglobin reductase

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.5.1 created 1961, deleted 1965

1.6.5.2 NAD(P)H dehydrogenase (quinone)

1.6.5.3 NADH:ubiquinone reductase (H⁺-translocating)

1.6.5.4 monodehydroascorbate reductase (NADH)

1.6.5.5 NADPH:quinone reductase

1.6.5.6 p-benzoquinone reductase (NADPH)

1.6.5.7 2-hydroxy-1,4-benzoquinone reductase

1.6.5.8 NADH:ubiquinone reductase (Na⁺-transporting)

1.6.5.9 NADH:quinone reductase (non-electrogenic)

1.6.5.10 NADPH dehydrogenase (quinone)

1.6.5.11 NADH dehydrogenase (quinone)

1.6.5.12 demethylphylloquinone reductase

1.6.6 With a nitrogenous group as acceptor

1.6.6.1 created 1961, deleted 2002

1.6.6.2 created 1961, deleted 2002

1.6.6.3 created 1961, deleted 2002

1.6.6.4 created 1961, deleted 2002

1.6.6.5 created 1961, deleted 1964

1.6.6.6 created 1961, deleted 2002

1.6.6.7 created 1961, deleted 2002

1.6.6.8 created 1965, deleted 2002

1.6.6.9 trimethylamine-N-oxide reductase

1.6.6.10 created 1972, deleted 2002

1.6.6.11 created 1972, deleted 2002

1.6.6.12 created 1989, deleted 2002

1.6.6.13 created 1989, deleted 2002

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)