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EC 1.6.1.1 Details

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EC number

1.6.1.1

Accepted name

NAD(P)⁺ transhydrogenase (Si-specific)

Reaction

NADPH + NAD⁺ = NADP⁺ + NADH

Other name(s)

pyridine nucleotide transhydrogenase, transhydrogenase, NAD(P)⁺ transhydrogenase, nicotinamide adenine dinucleotide (phosphate) transhydrogenase, NAD⁺ transhydrogenase, NADH transhydrogenase, nicotinamide nucleotide transhydrogenase, NADPH-NAD⁺ transhydrogenase, pyridine nucleotide transferase, NADPH-NAD⁺ oxidoreductase, NADH-NADP⁺-transhydrogenase, NADPH:NAD⁺ transhydrogenase, H⁺-Thase, non-energy-linked transhydrogenase, NADPH:NAD⁺ oxidoreductase (B-specific), NAD(P)⁺ transhydrogenase (B-specific)

Systematic name

NADPH:NAD⁺ oxidoreductase (Si-specific)

CAS registry number

9014-18-0

Comment

The enzyme from Azotobacter vinelandii is a flavoprotein (FAD). It is Si-specific with respect to both NAD⁺ and NADP⁺. Also acts on deamino coenzymes [cf. EC 1.6.1.2 NAD(P)⁺ transhydrogenase (Re/Si-specific)].

History

created 1961, modified 1986, modified 2013

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.3.1 D-aspartate oxidase

1.4.3.2 L-amino-acid oxidase

1.4.3.3 D-amino-acid oxidase

1.4.3.4 monoamine oxidase

1.4.3.5 pyridoxal 5′-phosphate synthase

1.4.3.6 amine oxidase (copper-containing)

1.4.3.7 D-glutamate oxidase

1.4.3.8 ethanolamine oxidase

1.4.3.9 created 1972, deleted 1984

1.4.3.10 putrescine oxidase

1.4.3.11 L-glutamate oxidase

1.4.3.12 cyclohexylamine oxidase

1.4.3.13 protein-lysine 6-oxidase

1.4.3.14 L-lysine oxidase

1.4.3.15 D-glutamate(D-aspartate) oxidase

1.4.3.16 L-aspartate oxidase

1.4.3.17 created 2000, deleted 2003

1.4.3.18 proposed 2000

1.4.3.19 glycine oxidase

1.4.3.20 L-lysine 6-oxidase

1.4.3.21 primary-amine oxidase

1.4.3.22 diamine oxidase

1.4.3.23 7-chloro-L-tryptophan oxidase

1.4.3.24 pseudooxynicotine oxidase

1.4.3.25 L-arginine oxidase

1.4.3.26 pre-mycofactocin synthase

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.1.1 NAD(P)⁺ transhydrogenase (Si-specific)

1.6.1.2 NAD(P)⁺ transhydrogenase (Re/Si-specific)

1.6.1.3 NAD(P)⁺ transhydrogenase

1.6.1.4 NAD(P)⁺ transhydrogenase (ferredoxin)

1.6.1.5 proton-translocating NAD(P)⁺ transhydrogenase

1.6.2 With a heme protein as acceptor

1.6.2.1 created 1961, deleted 1965

1.6.2.2 cytochrome-b₅ reductase

1.6.2.3 created 1972, deleted 1965

1.6.2.4 NADPH—hemoprotein reductase

1.6.2.5 NADPH—cytochrome-c₂ reductase

1.6.2.6 leghemoglobin reductase

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)