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EC 1.18.1.6 Details

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EC number

1.18.1.6

Accepted name

adrenodoxin-NADP⁺ reductase

Reaction

2 reduced adrenodoxin + NADP⁺ + H⁺ = 2 oxidized adrenodoxin + NADPH

Other name(s)

adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, AdR, NADPH:adrenal ferredoxin oxidoreductase, NADPH-adrenodoxin reductase

Systematic name

reduced adrenodoxin:NADP⁺ oxidoreductase

Comment

A flavoprotein (FAD). The enzyme, which transfers electrons from NADPH to adrenodoxin molecules, is the first component of the mitochondrial cytochrome P-450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones.

History

created 1965 as EC 1.6.99.4, transferred 1972 as EC 1.6.7.1, transferred 1978 to EC 1.18.1.2, part transferred 2012 to EC 1.18.1.6, modified 2016

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.2.1 created 1961, deleted 1965

1.6.2.2 cytochrome-b₅ reductase

1.6.2.3 created 1972, deleted 1965

1.6.2.4 NADPH—hemoprotein reductase

1.6.2.5 NADPH—cytochrome-c₂ reductase

1.6.2.6 leghemoglobin reductase

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.18.1 With NAD⁺ or NADP⁺ as acceptor

1.18.1.1 rubredoxin—NAD⁺ reductase

1.18.1.2 ferredoxin—NADP⁺ reductase

1.18.1.3 ferredoxin—NAD⁺ reductase

1.18.1.4 rubredoxin—NAD(P)⁺ reductase

1.18.1.5 putidaredoxin—NAD⁺ reductase

1.18.1.6 adrenodoxin-NADP⁺ reductase

1.18.1.7 ferredoxin—NAD(P)⁺ reductase (naphthalene dioxygenase ferredoxin-specific)

1.18.1.8 ferredoxin-NAD⁺ oxidoreductase (Na⁺-transporting)

1.18.2 With dinitrogen as acceptor (deleted sub-subclass)

1.18.3 With H⁺ as acceptor (deleted sub-subclass)

1.18.6 With dinitrogen as acceptor

1.18.96 With other, known, acceptors (deleted sub-subclass)

1.18.99 With H⁺ as acceptor (deleted sub-subclass)

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)