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EC 1.7.1.13 Details
EC number
1.7.1.13
Accepted name
preQ1 synthase
Reaction
7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+
Other name(s)
YkvM,
QueF,
preQ0 reductase,
preQ0 oxidoreductase,
7-cyano-7-deazaguanine reductase,
queuine synthase (incorrect as queuine is not the product),
queuine:NADP+ oxidoreductase (incorrect as queuine is not the product)
Systematic name
7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase
CAS registry number
1256460-80-6
Comment
The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queuosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, tRNA-guanosine34 transglycosylase. Queuosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies.
History
created 2006
EC Tree
1.2.4.3 created 1972, deleted 1978
1.7.1.8 created 2002, deleted 2002