EC Explorer

[browse EC tree] - [search]

EC 6.3.3.4 Details

show Brenda entry

EC number

6.3.3.4

Accepted name

(carboxyethyl)arginine β-lactam-synthase

Reaction

ATP + L-N²-(2-carboxyethyl)arginine = AMP + diphosphate + deoxyamidinoproclavaminate

Other name(s)

L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming)

Systematic name

L-N²-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming)

Comment

Forms part of the pathway for the biosythesis of the β-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It has been proposed [3] that L-N²-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the β-lactam ring is then formed by the intramolecular attack of the β-nitrogen on the activated carboxy group.

History

created 2003

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.2 With a cytochrome as acceptor

1.2.3 With oxygen as acceptor

1.2.4 With a disulfide as acceptor

1.2.5 With a quinone or similar compound as acceptor

1.2.7 With an iron-sulfur protein as acceptor

1.2.98 With other, known, physiological acceptors

1.2.99 With unknown physiological acceptors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.98.1. undefined

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

6.1 Forming carbon-oxygen bonds

6.2 Forming carbon-sulfur bonds

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.3 Cyclo-ligases

6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase

6.3.3.2 5-formyltetrahydrofolate cyclo-ligase

6.3.3.3 dethiobiotin synthase

6.3.3.4 (carboxyethyl)arginine β-lactam-synthase

6.3.3.5 O-ureido-D-serine cyclo-ligase

6.3.3.6 carbapenam-3-carboxylate synthase

6.3.3.7 Ni-sirohydrochlorin a,c-diamide reductive cyclase

6.3.4 Other carbon-nitrogen ligases

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.4 Forming carbon-carbon bonds

6.5 Forming phosphoric-ester bonds

6.6 Forming nitrogen—metal bonds

6.7 Forming nitrogen-nitrogen bonds

7 Translocases