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EC 1.2.5.2 Details

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EC number

1.2.5.2

Accepted name

aldehyde dehydrogenase (quinone)

Reaction

an aldehyde + a quinone + H₂O = a carboxylate + a quinol

Other name(s)

aldehyde dehydrogenase (acceptor)

Systematic name

aldehyde:quinone oxidoreductase

CAS registry number

75536-77-5

Comment

Wide specificity; acts on straight-chain aldehydes up to C₁₀, aromatic aldehydes, glyoxylate and glyceraldehyde. The enzymes contains a PQQ cofactor and multiple hemes that deliver the electrons to the membrane quinone pool.

History

created 1983 as EC 1.2.99.3, modified 1989, transferred 2015 to EC 1.2.5.2

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.2 With a cytochrome as acceptor

1.2.3 With oxygen as acceptor

1.2.4 With a disulfide as acceptor

1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)

1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)

1.2.4.3 created 1972, deleted 1978

1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

1.2.5 With a quinone or similar compound as acceptor

1.2.5.1 pyruvate dehydrogenase (quinone)

1.2.5.2 aldehyde dehydrogenase (quinone)

1.2.5.3 aerobic carbon monoxide dehydrogenase

1.2.7 With an iron-sulfur protein as acceptor

1.2.98 With other, known, physiological acceptors

1.2.99 With unknown physiological acceptors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.98.1. undefined

1.99 Other enzymes using O₂ as oxidant (deleted subclass)