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EC 1.14.14.57 Details
show Brenda entryEC number
1.14.14.57
Accepted name
taurochenodeoxycholate 6α-hydroxylase
Reaction
(1) taurochenodeoxycholate + [reduced NADPH—hemoprotein reductase] + O2 = taurohyocholate + [oxidized NADPH—hemoprotein reductase] + H2O;;(2) lithocholate + [reduced NADPH—hemoprotein reductase] + O2 = hyodeoxycholate + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
CYP3A4,
CYP4A21,
taurochenodeoxycholate 6α-monooxygenase
Systematic name
taurochenodeoxycholate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6α-hydroxylating)
CAS registry number
105669-85-0
Comment
A cytochrome P-450 (heme-thiolate) protein. Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid [5].
History
created 2005 asEC 1.14.13.97, transferred 2018 to EC 1.14.14.57
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
