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EC 1.14.21.6 Details
EC number
1.14.21.6
Accepted name
lathosterol oxidase
Reaction
5α-cholest-7-en-3β-ol + NAD(P)H + H+ + O2 = cholesta-5,7-dien-3β-ol + NAD(P)+ + 2 H2O
Other name(s)
Δ7-sterol Δ5-dehydrogenase,
Δ7-sterol 5-desaturase,
Δ7-sterol-C5(6)-desaturase,
5-DES
Systematic name
5α-cholest-7-en-3β-ol,NAD(P)H:oxygen 5-oxidoreductase
CAS registry number
37255-37-1
Comment
This enzyme catalyses the introduction of a C5 double bond into the B ring of Δ7-sterols to yield the corresponding Δ5,7-sterols in mammals, yeast and plants [4]. Forms part of the plant sterol biosynthesis pathway.
History
created 1972 as EC 1.3.3.2, transferred 2005 to EC 1.14.21.6, deleted 2015
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