EC Explorer

1.21.4.5

tetrachlorohydroquinone reductive dehalogenase

(1) 2,6-dichlorohydroquinone + Cl^- + glutathione disulfide = 2,3,6-trichlorohydroquinone + 2 glutathione;;(2) 2,3,6-trichlorohydroquinone + Cl^- + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione

pcpC (gene name)

glutathione disulfide:2,6-dichlorohydroquinone (chlorinating)

The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, converts tetrachlorohydroquinone to 2,6-dichlorohydroquinone in two steps, via 2,3,6-trichlorohydroquinone, using glutathione as the reducing agent. The enzyme is sensitive to oxidation - when an internal L-cysteine residue is oxidized, the enzyme produces 2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone and 2,6-dichloro-3-(glutathion-S-yl)-hydroquinone instead of its normal products.

created 2018