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EC 3.5.3.15 Details
EC number
3.5.3.15
Accepted name
protein-arginine deiminase
Reaction
protein L-arginine + H2O = protein L-citrulline + NH3
Other name(s)
peptidylarginine deiminase, PAD
Systematic name
protein-L-arginine iminohydrolase
CAS registry number
75536-80-0
Comment
Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.
History
created 1983
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.3 With oxygen as acceptor
1.5.4 With a disulfide as acceptor
1.5.5 With a quinone or similar compound as acceptor
1.5.7 With an iron-sulfur protein as acceptor
1.5.8 With a flavin or flavoprotein as acceptor
1.5.98 With other, known, physiological acceptors
1.5.99 With unknown physiological acceptors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.1 With NAD+ or NADP+ as acceptor
1.21.3 With oxygen as acceptor
1.21.4 With a disulfide as acceptor
1.21.98 With other, known, physiological acceptors
1.21.99 With unknown physiological acceptors
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.2 In cyclic amides
3.5.3 In linear amidines
3.5.3.1 arginase
3.5.3.2 guanidinoacetase
3.5.3.3 creatinase
3.5.3.4 allantoicase
3.5.3.5 formimidoylaspartate deiminase
3.5.3.6 arginine deiminase
3.5.3.7 guanidinobutyrase
3.5.3.8 formimidoylglutamase
3.5.3.9 allantoate deiminase
3.5.3.10 D-arginase
3.5.3.11 agmatinase
3.5.3.12 agmatine deiminase
3.5.3.13 formimidoylglutamate deiminase
3.5.3.14 amidinoaspartase
3.5.3.15 protein-arginine deiminase
3.5.3.16 methylguanidinase
3.5.3.17 guanidinopropionase
3.5.3.18 dimethylargininase
3.5.3.19 ureidoglycolate hydrolase
3.5.3.20 diguanidinobutanase
3.5.3.21 methylenediurea deaminase
3.5.3.22 proclavaminate amidinohydrolase
3.5.3.23 N-succinylarginine dihydrolase
3.5.3.24 N1-aminopropylagmatine ureohydrolase
3.5.3.25 Nω-hydroxy-L-arginine amidinohydrolase
3.5.3.26 (S)-ureidoglycine aminohydrolase
3.5.4 In cyclic amidines
3.5.5 In nitriles
3.5.99 In other compounds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases