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EC 3.1.4.59 Details
EC number
3.1.4.59
Accepted name
cyclic-di-AMP phosphodiesterase
Reaction
cyclic di-3′,5′-adenylate + H2O = 5′-O-phosphonoadenylyl-(3′→5′)-adenosine
Other name(s)
gdpP (gene name)
Systematic name
cyclic bis(3′→5′)diadenylate 3′-adenylylhydrolase
Comment
The enzyme, described from Gram-positive bacteria, degrades the second messenger cyclic di-3′,5′-adenylate. It is a membrane-bound protein that contains a cytoplasmic facing Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1 domain, which confers the phosphodiesterase activity. Activity requires Mn2+ and is inhibited by pApA.
History
created 2019
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.2.1 With NAD+ or NADP+ as acceptor
1.2.2 With a cytochrome as acceptor
1.2.3 With oxygen as acceptor
1.2.4 With a disulfide as acceptor
1.2.5 With a quinone or similar compound as acceptor
1.2.7 With an iron-sulfur protein as acceptor
1.2.98 With other, known, physiological acceptors
1.2.99 With unknown physiological acceptors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.1 With NAD+ or NADP+ as acceptor
1.21.3 With oxygen as acceptor
1.21.4 With a disulfide as acceptor
1.21.98 With other, known, physiological acceptors
1.21.99 With unknown physiological acceptors
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.2 Thioester hydrolases
3.1.3 Phosphoric-monoester hydrolases
3.1.4 Phosphoric-diester hydrolases
3.1.4.1 phosphodiesterase I
3.1.4.2 glycerophosphocholine phosphodiesterase
3.1.4.3 phospholipase C
3.1.4.4 phospholipase D
3.1.4.5 created 1961, deleted 1978
3.1.4.6 created 1961, deleted 1978
3.1.4.7 created 1961, deleted 1978
3.1.4.8 created 1961, transferred 1965 to EC 2.7.7.26, reinstated 1972, deleted 1978
3.1.4.9 created 1965, deleted 1978
3.1.4.10 created 1972, modified 1976, deleted 2002
3.1.4.11 phosphoinositide phospholipase C
3.1.4.12 sphingomyelin phosphodiesterase
3.1.4.13 serine-ethanolaminephosphate phosphodiesterase
3.1.4.14 [acyl-carrier-protein] phosphodiesterase
3.1.4.15 adenylyl-[glutamate—ammonia ligase] hydrolase
3.1.4.16 2′,3′-cyclic-nucleotide 2′-phosphodiesterase
3.1.4.17 3′,5′-cyclic-nucleotide phosphodiesterase
3.1.4.18 created 1972, deleted 1978
3.1.4.19 created 1972, deleted 1978
3.1.4.20 created 1972, deleted 1978
3.1.4.21 created 1972, deleted 1978
3.1.4.22 created 1972, deleted 1978
3.1.4.23 created 1972, deleted 1978
3.1.4.24 created 1972, deleted 1978
3.1.4.25 created 1972, deleted 1978
3.1.4.26 created 1972, deleted 1978
3.1.4.27 created 1972, deleted 1978
3.1.4.28 created 1972, deleted 1978
3.1.4.29 created 1972, deleted 1978
3.1.4.30 created 1972, deleted 1978
3.1.4.31 created 1972, deleted 1978
3.1.4.32 created 1972, deleted 1978
3.1.4.33 created 1972, deleted 1978
3.1.4.34 created 1972, deleted 1978
3.1.4.35 3′,5′-cyclic-GMP phosphodiesterase
3.1.4.36 created 1976, deleted 2002
3.1.4.37 2′,3′-cyclic-nucleotide 3′-phosphodiesterase
3.1.4.38 glycerophosphocholine cholinephosphodiesterase
3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase
3.1.4.40 CMP-N-acylneuraminate phosphodiesterase
3.1.4.41 sphingomyelin phosphodiesterase D
3.1.4.42 glycerol-1,2-cyclic-phosphate 2-phosphodiesterase
3.1.4.43 glycerophosphoinositol inositolphosphodiesterase
3.1.4.44 glycerophosphoinositol glycerophosphodiesterase
3.1.4.45 N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase
3.1.4.46 glycerophosphodiester phosphodiesterase
3.1.4.47 created 1989, deleted 2002
3.1.4.48 dolichylphosphate-glucose phosphodiesterase
3.1.4.49 dolichylphosphate-mannose phosphodiesterase
3.1.4.50 glycosylphosphatidylinositol phospholipase D
3.1.4.51 glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase
3.1.4.52 cyclic-guanylate-specific phosphodiesterase
3.1.4.53 3′,5′-cyclic-AMP phosphodiesterase
3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
3.1.4.55 phosphoribosyl 1,2-cyclic phosphate phosphodiesterase
3.1.4.56 7,8-dihydroneopterin 2′,3′-cyclic phosphate phosphodiesterase
3.1.4.57 phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
3.1.4.58 RNA 2′,3′-cyclic 3′-phosphodiesterase
3.1.4.59 cyclic-di-AMP phosphodiesterase
3.1.4.60 pApA phosphodiesterase
3.1.4.61 cyclic 2,3-diphosphoglycerate hydrolase
3.1.5 Triphosphoric-monoester hydrolases
3.1.6 Sulfuric-ester hydrolases
3.1.7 Diphosphoric-monoester hydrolases
3.1.8 Phosphoric-triester hydrolases
3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters
3.1.12 Exodeoxyribonucleases producing 3′-phosphomonoesters
3.1.13 Exoribonucleases producing 5′-phosphomonoesters
3.1.14 Exoribonucleases producing 3'-phosphomonoesters
3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters
3.1.23 Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass)
3.1.24 Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass)
3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases
3.1.26 Endoribonucleases producing 5'-phosphomonoesters
3.1.27 Endoribonucleases producing 3'-phosphomonoesters
3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases