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EC 3.1.6.1 Details
show Brenda entryEC number
3.1.6.1
Accepted name
arylsulfatase (type I)
Reaction
an aryl sulfate + H2O = a phenol + sulfate
Other name(s)
sulfatase,
nitrocatechol sulfatase,
phenolsulfatase,
phenylsulfatase,
p-nitrophenyl sulfatase,
arylsulfohydrolase,
4-methylumbelliferyl sulfatase,
estrogen sulfatase,
type I sulfatase,
arylsulfatase
Systematic name
aryl-sulfate sulfohydrolase
CAS registry number
9016-17-5
Comment
Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-β-lactamase fold and binds two zinc ions as cofactors. Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities. The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate. This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC 1.8.3.7, formylglycine-generating enzyme, EC 1.1.98.7, serine-type anaerobic sulfatase-maturating enzyme, or EC 1.8.98.7, cysteine-type anaerobic sulfatase-maturating enzyme.
History
created 1961, modified 2011, modified 2021
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
3.1.6.5 created 1961, deleted 1964
