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EC 3.4.13.19 Details
EC number
3.4.13.19
Accepted name
membrane dipeptidase
Reaction
Hydrolysis of dipeptides
Other name(s)
renal dipeptidase, dehydropeptidase I (DPH I), dipeptidase (ambiguous), aminodipeptidase, dipeptide hydrolase (ambiguous), dipeptidyl hydrolase (ambiguous), nonspecific dipeptidase, glycosyl-phosphatidylinositol-anchored renal dipeptidase, MDP
CAS registry number
9031-99-6
Comment
A membrane-bound, zinc enzyme with broad specificity. Abundant in the kidney cortex. Inhibited by bestatin and cilastatin. Type example of peptidase family M19.
History
created 1961 as EC 3.4.3.1 and EC 3.4.3.2, transferred 1972 to EC 3.4.13.1 and EC 3.4.13.2, transferred 1978 to EC 3.4.13.11, part transferred 1992 to EC 3.4.13.19, modified 2011
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.2 With a cytochrome as acceptor
1.1.3 With oxygen as acceptor
1.1.4 With a disulfide as acceptor
1.1.5 With a quinone or similar compound as acceptor
1.1.7 With an iron-sulfur protein as acceptor
1.1.9 With a copper protein as acceptor
1.1.98 With other, known, physiological acceptors
1.1.99 With unknown physiological acceptors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.1 With NAD+ or NADP+ as acceptor
1.21.3 With oxygen as acceptor
1.21.4 With a disulfide as acceptor
1.21.98 With other, known, physiological acceptors
1.21.99 With unknown physiological acceptors
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.4.1 α-Amino-acyl-peptide hydrolases (deleted sub-subclass)
3.4.2 Peptidyl-amino-acid hydrolases (deleted sub-subclass)
3.4.3 Dipeptide hydrolases (deleted sub-subclass)
3.4.4 Peptidyl peptide hydrolases (deleted sub-subclass)
3.4.11 Aminopeptidases
3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)
3.4.13 Dipeptidases
3.4.13.1 created 1972, deleted 1978 [transferred to EC 3.4.13.11, deleted 1992]
3.4.13.2 created 1972, deleted 1978 [transferred to EC 3.4.13.11, deleted 1992]
3.4.13.3 Xaa-His dipeptidase
3.4.13.4 Xaa-Arg dipeptidase
3.4.13.5 Xaa-methyl-His dipeptidase
3.4.13.6 created 1961 as EC 3.4.3.5, transferred 1972 to EC 3.4.13.6
3.4.13.7 Glu-Glu dipeptidase
3.4.13.8 created 1961 as EC 3.4.3.6, transferred 1972 to EC 3.4.13.8
3.4.13.9 Xaa-Pro dipeptidase
3.4.13.10 created 1972, deleted 1992
3.4.13.11 created 1972, deleted 1992
3.4.13.12 Met-Xaa dipeptidase
3.4.13.13 created 1981, deleted 1992
3.4.13.14 created 1989, deleted 1992
3.4.13.15 created 1989, deleted 1992
3.4.13.16 created 1989, deleted 1992
3.4.13.17 non-stereospecific dipeptidase
3.4.13.18 cytosol nonspecific dipeptidase
3.4.13.19 membrane dipeptidase
3.4.13.20 β-Ala-His dipeptidase
3.4.13.21 dipeptidase E
3.4.13.22 D-Ala-D-Ala dipeptidase
3.4.13.23 cysteinylglycine-S-conjugate dipeptidase
3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
3.4.15 Peptidyl-dipeptidases
3.4.16 Serine-type carboxypeptidases
3.4.17 Metallocarboxypeptidases
3.4.18 Cysteine-type carboxypeptidases
3.4.19 Omega peptidases
3.4.21 Serine endopeptidases
3.4.22 Cysteine endopeptidases
3.4.23 Aspartic endopeptidases
3.4.24 Metalloendopeptidases
3.4.25 Threonine endopeptidases
3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases