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EC 1.3.1.48 Details
EC number
1.3.1.48
Accepted name
13,14-dehydro-15-oxoprostaglandin 13-reductase
Reaction
11α-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (13E)-11α-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+
Other name(s)
15-oxo-Δ13-prostaglandin reductase,
Δ13-15-ketoprostaglandin reductase,
15-ketoprostaglandin Δ13-reductase,
prostaglandin Δ13-reductase,
prostaglandin 13-reductase,
(5Z)-(15S)-11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase,
(5Z)-11α-hydroxy-9,15-dioxoprost-5-enoate:NAD(P)+ Δ13-oxidoreductase
Systematic name
11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase
CAS registry number
57406-74-3
Comment
Reduces 13,14-dehydro-15-oxoprostaglandins to 13,14-dihydro derivatives. The enzyme from placenta is specific for NAD+.
History
created 1990, modified 2014
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004