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EC 1.14.17.3 Details
show Brenda entryEC number
1.14.17.3
Accepted name
peptidylglycine monooxygenase
Reaction
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O
Other name(s)
peptidylglycine 2-hydroxylase,
peptidyl α-amidating enzyme,
peptide-α-amide synthetase,
peptide α-amidating enzyme,
peptide α-amide synthase,
peptidylglycine α-hydroxylase,
peptidylglycine α-amidating monooxygenase,
PAM-A,
PAM-B,
PAM,
peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
Systematic name
[peptide]-glycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
CAS registry number
90597-47-0
Comment
A copper protein. The enzyme binds two copper ions with distinct roles during catalysis. Peptidylglycines with a neutral amino acid residue in the penultimate position are the best substrates for the enzyme. The product is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide, a reaction catalysed by EC 4.3.2.5 peptidylamidoglycolate lyase. In mammals, the two activities are part of a bifunctional protein. Involved in the final step of biosynthesis of α-melanotropin and related biologically active peptides.
History
created 1989, modified 2019
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003 1.14.17.2 created 1972, deleted 1984
