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EC 1.6.1.5 Details

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EC number

1.6.1.5

Accepted name

proton-translocating NAD(P)⁺ transhydrogenase

Reaction

NADPH + NAD⁺ + H⁺_{[side 1]} = NADP⁺ + NADH + H⁺_{[side 2]}

Other name(s)

pntA (gene name), pntB (gene name), NNT (gene name)

Systematic name

NADPH:NAD⁺ oxidoreductase (H⁺-transporting)

Comment

The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme.

History

created 2015, deleted 2018

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.1.1 NAD(P)⁺ transhydrogenase (Si-specific)

1.6.1.2 NAD(P)⁺ transhydrogenase (Re/Si-specific)

1.6.1.3 NAD(P)⁺ transhydrogenase

1.6.1.4 NAD(P)⁺ transhydrogenase (ferredoxin)

1.6.1.5 proton-translocating NAD(P)⁺ transhydrogenase

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.4.1 created 1961, deleted 2002

1.6.4.2 created 1961, modified 1989, deleted 2002

1.6.4.3 created 1961, modified 1976, deleted 1983

1.6.4.4 created 1965, deleted 2002

1.6.4.5 created 1972, deleted 2002

1.6.4.6 created 1972, deleted 2002

1.6.4.7 created 1978, deleted 2002

1.6.4.8 created 1989, deleted 2002

1.6.4.9 created 1992, deleted 2002

1.6.4.10 created 1992, deleted 2002

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.7.1 created 1972, deleted 1978

1.6.7.2 created 1972, deleted 1978

1.6.7.3 created 1978, deleted 1978

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)