EC Explorer
[browse EC tree] - [search]
EC 1.14.19.7 Details
show Brenda entryEC number
1.14.19.7
Accepted name
(S)-2-hydroxypropylphosphonic acid epoxidase
Reaction
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2 = (1R,2S)-epoxypropylphosphonate + NAD+ + 2 H2O
Other name(s)
HPP epoxidase,
HppE,
2-hydroxypropylphosphonic acid epoxidase,
Fom4,
(S)-2-hydroxypropylphosphonate epoxidase
Systematic name
(S)-2-hydroxypropylphosphonate,NADH:oxygen epoxidase
Comment
Contains one non-heme iron centre per monomer [1,5]. FMN is required to mediate the transfer of reducing equivalents from NADH to the active site iron [1]. This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species.
History
created 2011, deleted 2014
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002
