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EC 1.21.99.3 Details
show Brenda entryEC number
1.21.99.3
Accepted name
thyroxine 5-deiodinase
Reaction
3,3′,5′-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
Other name(s)
diiodothyronine 5′-deiodinase (ambiguous),
iodothyronine 5-deiodinase,
iodothyronine inner ring monodeiodinase,
type III iodothyronine deiodinase
Systematic name
3,3′,5′-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
CAS registry number
74506-30-2
Comment
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
History
created 2003 as EC 1.97.1.11, transferred 2015 to EC 1.21.99.3
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
