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EC 1.3.5.4 Details
show Brenda entryEC number
1.3.5.4
Accepted name
fumarate reductase (quinol)
Reaction
succinate + a quinone = fumarate + a quinol
Other name(s)
FRD,
menaquinol-fumarate oxidoreductase,
succinate dehydrogenase (menaquinone),
succinate:menaquinone oxidoreductase,
fumarate reductase (menaquinone),
complex II (ambiguous)
Systematic name
succinate:quinone oxidoreductase
Comment
The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, succinate dehydrogenase (quinone), to which it is closely related.
History
created 2010, modified 2013, deleted 2022
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002 1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
