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EC 1.3.1.82 Details
show Brenda entryEC number
1.3.1.82
Accepted name
(-)-isopiperitenone reductase
Reaction
(+)-cis-isopulegone + NADP+ = (-)-isopiperitenone + NADPH + H+
Systematic name
(+)-cis-isopulegone:NADP+ oxidoreductase
Comment
The reaction occurs in the opposite direction to that shown above. The enzyme participates in the menthol-biosynthesis pathway of Mentha plants. (+)-Pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates. The enzyme has a preference for NADPH as the reductant, with NADH being a poor substitute [2]. The enzyme is highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product. It is a member of the short-chain dehydrogenase/reductase superfamily.
History
created 2008
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002 1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003 1.3.1.23 created 1972, deleted 2005 1.3.1.50 created 1992, deleted 1999 1.3.1.55 created 1999, deleted 2004
