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EC 1.21.3.7 Details
EC number
1.21.3.7
Accepted name
tetrahydrocannabinolic acid synthase
Reaction
cannabigerolate + O2 = Δ9-tetrahydrocannabinolate + H2O2
Other name(s)
THCA synthase,
Δ1-tetrahydrocannabinolic acid synthase
Systematic name
cannabigerolate:oxygen oxidoreductase (cyclizing, Δ9-tetrahydrocannabinolate-forming)
Comment
A flavoprotein (FAD). The cofactor is covalently bound. Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Δ9-THCA with lower efficiency. Whereas the product was originally called Δ1-tetrahydrocannabinolate, the recommended name according to systematic peripheral numbering is Δ9-tetrahydrocannabinolate.
History
created 2012
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003