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EC 1.21.3.10 Details
show Brenda entryEC number
1.21.3.10
Accepted name
hercynylcysteine S-oxide synthase
Reaction
hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
Other name(s)
Egt1,
Egt-1
Systematic name
hercynine,L-cysteine:oxygen [S-(hercyn-2-yl)-L-cysteine S-oxide-forming]
Comment
Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nα-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine.
History
created 2015 as 1.14.99.51, transferred 2022 to EC 1.21.3.10
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.8.99.4 created 1999, deleted 2000
