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EC 1.8.4.14 Details
show Brenda entryEC number
1.8.4.14
Accepted name
L-methionine (R)-S-oxide reductase
Reaction
L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin
Other name(s)
fRMsr,
FRMsr,
free met-R-(o) reductase,
free-methionine (R)-S-oxide reductase
Systematic name
L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming]
CAS registry number
945954-12-1
Comment
Requires NADPH. Unlike EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC 1.8.4.13, L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate.
History
created 1984 as EC 1.8.4.5, part transferred 2006 to EC 1.8.4.14
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.5.1 created 1983, deleted 2002
