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EC 1.8.4.5 Details

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EC number

1.8.4.5

Accepted name

methionine-S-oxide reductase

Reaction

L-methionine + thioredoxin disulfide + H₂O = L-methionine S-oxide + thioredoxin

Other name(s)

methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionine:oxidized-thioredoxin S-oxidoreductase

Systematic name

L-methionine:thioredoxin-disulfide S-oxidoreductase

CAS registry number

70248-65-6

Comment

In the reverse reaction, dithiothreitol can replace reduced thioredoxin, and other methyl sulfoxides can replace methionine sulfoxide.

History

created 1984, deleted 2006

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.3.1 D-aspartate oxidase

1.4.3.2 L-amino-acid oxidase

1.4.3.3 D-amino-acid oxidase

1.4.3.4 monoamine oxidase

1.4.3.5 pyridoxal 5′-phosphate synthase

1.4.3.6 amine oxidase (copper-containing)

1.4.3.7 D-glutamate oxidase

1.4.3.8 ethanolamine oxidase

1.4.3.9 created 1972, deleted 1984

1.4.3.10 putrescine oxidase

1.4.3.11 L-glutamate oxidase

1.4.3.12 cyclohexylamine oxidase

1.4.3.13 protein-lysine 6-oxidase

1.4.3.14 L-lysine oxidase

1.4.3.15 D-glutamate(D-aspartate) oxidase

1.4.3.16 L-aspartate oxidase

1.4.3.17 created 2000, deleted 2003

1.4.3.18 proposed 2000

1.4.3.19 glycine oxidase

1.4.3.20 L-lysine 6-oxidase

1.4.3.21 primary-amine oxidase

1.4.3.22 diamine oxidase

1.4.3.23 7-chloro-L-tryptophan oxidase

1.4.3.24 pseudooxynicotine oxidase

1.4.3.25 L-arginine oxidase

1.4.3.26 pre-mycofactocin synthase

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.4.99.1 D-amino-acid dehydrogenase

1.4.99.2 taurine dehydrogenase

1.4.99.3 amine dehydrogenase

1.4.99.4 aralkylamine dehydrogenase

1.4.99.5 glycine dehydrogenase (cyanide-forming)

1.4.99.6 D-arginine dehydrogenase

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.2 With a cytochrome as acceptor

1.8.3 With oxygen as acceptor

1.8.4 With a disulfide as acceptor

1.8.4.1 glutathione—homocystine transhydrogenase

1.8.4.2 protein-disulfide reductase (glutathione)

1.8.4.3 glutathione—CoA-glutathione transhydrogenase

1.8.4.4 glutathione—cystine transhydrogenase

1.8.4.5 methionine-S-oxide reductase

1.8.4.6 protein-methionine-S-oxide reductase

1.8.4.7 enzyme-thiol transhydrogenase (glutathione-disulfide)

1.8.4.8 phosphoadenylyl-sulfate reductase (thioredoxin)

1.8.4.9 adenylyl-sulfate reductase (glutathione)

1.8.4.10 adenylyl-sulfate reductase (thioredoxin)

1.8.4.11 peptide-methionine (S)-S-oxide reductase

1.8.4.12 peptide-methionine (R)-S-oxide reductase

1.8.4.13 L-methionine (S)-S-oxide reductase

1.8.4.14 L-methionine (R)-S-oxide reductase

1.8.4.15 protein dithiol oxidoreductase (disulfide-forming)

1.8.4.16 thioredoxin:protein disulfide reductase

1.8.5 With a quinone or similar compound as acceptor

1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

1.8.7 With an iron-sulfur protein as acceptor

1.8.98 With other, known, physiological acceptors

1.8.99 With unknown physiological acceptors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)