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EC 1.14.11.8 Details
EC number
1.14.11.8
Accepted name
trimethyllysine dioxygenase
Reaction
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
Other name(s)
trimethyllysine α-ketoglutarate dioxygenase,
TML-α-ketoglutarate dioxygenase,
TML hydroxylase,
6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Systematic name
N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
CAS registry number
74622-49-4
Comment
Requires Fe2+ and ascorbate.
History
created 1983
EC Tree
1.14.11.5 created 1972, deleted 1976