EC Explorer

[browse EC tree] - [search]

EC 1.8.4.15 Details

show Brenda entry

EC number

1.8.4.15

Accepted name

protein dithiol oxidoreductase (disulfide-forming)

Reaction

a [DsbA protein] carrying a disulfide bond + a [protein] with reduced L-cysteine residues = a [DsbA protein] with reduced L-cysteine residues + a [protein] carrying a disulfide bond

Other name(s)

dsbA (gene name)

Systematic name

protein dithiol:[DsbA protein] oxidoreductase (protein disulfide-forming)

Comment

DsbA is a periplasmic thiol:disulfide oxidoreductase found in Gram-negative bacteria that promotes protein disulfide bond formation. DsbA contains a redox active disulfide bond that is catalytically transferred via disulfide exchange to a diverse range of newly translocated protein substrates. The protein is restored to the oxidized state by EC 1.8.5.9, protein dithiol:quinone oxidoreductase DsbB.

History

created 2019

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.1.1 NAD(P)⁺ transhydrogenase (Si-specific)

1.6.1.2 NAD(P)⁺ transhydrogenase (Re/Si-specific)

1.6.1.3 NAD(P)⁺ transhydrogenase

1.6.1.4 NAD(P)⁺ transhydrogenase (ferredoxin)

1.6.1.5 proton-translocating NAD(P)⁺ transhydrogenase

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.6.1 created 1961, deleted 2002

1.6.6.2 created 1961, deleted 2002

1.6.6.3 created 1961, deleted 2002

1.6.6.4 created 1961, deleted 2002

1.6.6.5 created 1961, deleted 1964

1.6.6.6 created 1961, deleted 2002

1.6.6.7 created 1961, deleted 2002

1.6.6.8 created 1965, deleted 2002

1.6.6.9 trimethylamine-N-oxide reductase

1.6.6.10 created 1972, deleted 2002

1.6.6.11 created 1972, deleted 2002

1.6.6.12 created 1989, deleted 2002

1.6.6.13 created 1989, deleted 2002

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.2 With a cytochrome as acceptor

1.8.3 With oxygen as acceptor

1.8.4 With a disulfide as acceptor

1.8.4.1 glutathione—homocystine transhydrogenase

1.8.4.2 protein-disulfide reductase (glutathione)

1.8.4.3 glutathione—CoA-glutathione transhydrogenase

1.8.4.4 glutathione—cystine transhydrogenase

1.8.4.5 methionine-S-oxide reductase

1.8.4.6 protein-methionine-S-oxide reductase

1.8.4.7 enzyme-thiol transhydrogenase (glutathione-disulfide)

1.8.4.8 phosphoadenylyl-sulfate reductase (thioredoxin)

1.8.4.9 adenylyl-sulfate reductase (glutathione)

1.8.4.10 adenylyl-sulfate reductase (thioredoxin)

1.8.4.11 peptide-methionine (S)-S-oxide reductase

1.8.4.12 peptide-methionine (R)-S-oxide reductase

1.8.4.13 L-methionine (S)-S-oxide reductase

1.8.4.14 L-methionine (R)-S-oxide reductase

1.8.4.15 protein dithiol oxidoreductase (disulfide-forming)

1.8.4.16 thioredoxin:protein disulfide reductase

1.8.5 With a quinone or similar compound as acceptor

1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

1.8.7 With an iron-sulfur protein as acceptor

1.8.98 With other, known, physiological acceptors

1.8.99 With unknown physiological acceptors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)