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EC 1.8.1.7 Details

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EC number

1.8.1.7

Accepted name

glutathione-disulfide reductase

Reaction

2 glutathione + NADP⁺ = glutathione disulfide + NADPH + H⁺

Other name(s)

glutathione reductase, glutathione reductase (NADPH), NADPH-glutathione reductase, GSH reductase, GSSG reductase, NADPH-GSSG reductase, glutathione S-reductase, NADPH:oxidized-glutathione oxidoreductase

Systematic name

glutathione:NADP⁺ oxidoreductase

CAS registry number

9001-48-3

Comment

A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres.

History

created 1961 as EC 1.6.4.2, modified 1989, transferred 2002 to EC 1.8.1.7

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.1.1 created 1961, deleted 1972

1.8.1.2 assimilatory sulfite reductase (NADPH)

1.8.1.3 hypotaurine dehydrogenase

1.8.1.4 dihydrolipoyl dehydrogenase

1.8.1.5 2-oxopropyl-CoM reductase (carboxylating)

1.8.1.6 cystine reductase

1.8.1.7 glutathione-disulfide reductase

1.8.1.8 protein-disulfide reductase

1.8.1.9 thioredoxin-disulfide reductase

1.8.1.10 CoA-glutathione reductase

1.8.1.11 asparagusate reductase

1.8.1.12 trypanothione-disulfide reductase

1.8.1.13 bis-γ-glutamylcystine reductase

1.8.1.14 CoA-disulfide reductase

1.8.1.15 mycothione reductase

1.8.1.16 glutathione amide reductase

1.8.1.17 dimethylsulfone reductase

1.8.1.18 NAD(P)H sulfur oxidoreductase (CoA-dependent)

1.8.1.19 sulfide dehydrogenase

1.8.1.20 4,4′-dithiodibutanoate disulfide reductase

1.8.1.21 dissimilatory dimethyldisulfide reductase

1.8.2 With a cytochrome as acceptor

1.8.3 With oxygen as acceptor

1.8.4 With a disulfide as acceptor

1.8.5 With a quinone or similar compound as acceptor

1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

1.8.6.1 created 1961, deleted 1976

1.8.7 With an iron-sulfur protein as acceptor

1.8.98 With other, known, physiological acceptors

1.8.99 With unknown physiological acceptors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)