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EC 1.8.3.5 Details
show Brenda entryEC number
1.8.3.5
Accepted name
prenylcysteine oxidase
Reaction
an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2
Other name(s)
prenylcysteine lyase
Systematic name
S-prenyl-L-cysteine:oxygen oxidoreductase
CAS registry number
196717-99-4
Comment
A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18.
History
created 2000 as EC 4.4.1.18, transferred 2002 to EC 1.8.3.5
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
