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EC 1.8.4.14 Details
show Brenda entryEC number
1.8.4.14
Accepted name
L-methionine (R)-S-oxide reductase
Reaction
L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin
Other name(s)
fRMsr,
FRMsr,
free met-R-(o) reductase,
free-methionine (R)-S-oxide reductase
Systematic name
L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming]
CAS registry number
945954-12-1
Comment
Requires NADPH. Unlike EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC 1.8.4.13, L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate.
History
created 1984 as EC 1.8.4.5, part transferred 2006 to EC 1.8.4.14
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002
