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EC 3.6.5.6 Details

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EC number

3.6.5.6

Accepted name

tubulin GTPase

Reaction

GTP + H₂O = GDP + phosphate

Systematic name

GTP phosphohydrolase (microtubule-releasing)

Comment

An intrinsic activity of α-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.

History

created 2000 as EC 3.6.1.51, transferred 2003 to EC 3.6.5.6

EC Tree

1 Oxidoreductases

2 Transferases

3 Hydrolases

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.2 In sulfonyl-containing anhydrides

3.6.3 Acting on acid anhydrides to catalyse transmembrane movement of substances

3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement

3.6.4.1 myosin ATPase

3.6.4.2 dynein ATPase

3.6.4.3 microtubule-severing ATPase

3.6.4.4 plus-end-directed kinesin ATPase

3.6.4.5 minus-end-directed kinesin ATPase

3.6.4.6 vesicle-fusing ATPase

3.6.4.7 peroxisome-assembly ATPase

3.6.4.8 proteasome ATPase

3.6.4.9 chaperonin ATPase

3.6.4.10 non-chaperonin molecular chaperone ATPase

3.6.4.11 nucleoplasmin ATPase

3.6.4.12 DNA helicase

3.6.4.13 RNA helicase

3.6.5 Acting on GTP to facilitate cellular and subcellular movement

3.6.5.1 heterotrimeric G-protein GTPase

3.6.5.2 small monomeric GTPase

3.6.5.3 protein-synthesizing GTPase

3.6.5.4 signal-recognition-particle GTPase

3.6.5.5 dynamin GTPase

3.6.5.6 tubulin GTPase

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds