Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

[browse EC tree] - [search]
EC 3.6.1.74 Details
EC number
3.6.1.74
Accepted name
mRNA 5′-phosphatase
Reaction
a 5′-triphospho-[mRNA] + H2O = a 5′-diphospho-[mRNA] + phosphate
Other name(s)
5′-polynucleotidase, polynucleotide 5′-phosphohydrolase, RNGTT (gene name), CET1 (gene name), mRNA 5′-triphosphate monophosphatase
Systematic name
5′-triphospho-mRNA 5′-phosphohydrolase
Comment
The enzyme, found in eukaryotes and some plus strand RNA viruses (e.g. alphavirus), is involved in mRNA capping. Unlike the eukaryotic enzyme, the viral enzyme requires a purine in the first position of the mRNA. The human enzyme is a multi domain protein that also has the activity of EC 2.7.7.50, mRNA guanylyltransferase.
History
created 2021
back to top
EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.6.1 In phosphorus-containing anhydrides
3.6.1.1 inorganic diphosphatase
3.6.1.2 trimetaphosphatase
3.6.1.3 adenosinetriphosphatase
3.6.1.4 created 1961, deleted 1965
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.7 acylphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
3.6.1.10 endopolyphosphatase
3.6.1.11 exopolyphosphatase
3.6.1.12 dCTP diphosphatase
3.6.1.13 ADP-ribose diphosphatase
3.6.1.14 adenosine-tetraphosphatase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.16 CDP-glycerol diphosphatase
3.6.1.17 bis(5′-nucleosyl)-tetraphosphatase (asymmetrical)
3.6.1.18 FAD diphosphatase
3.6.1.19 nucleoside-triphosphate diphosphatase
3.6.1.20 5′-acylphosphoadenosine hydrolase
3.6.1.21 ADP-sugar diphosphatase
3.6.1.22 NAD+ diphosphatase
3.6.1.23 dUTP diphosphatase
3.6.1.24 nucleoside phosphoacylhydrolase
3.6.1.25 triphosphatase
3.6.1.26 CDP-diacylglycerol diphosphatase
3.6.1.27 undecaprenyl-diphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.29 bis(5′-adenosyl)-triphosphatase
3.6.1.30 m7G(5′)pppN diphosphatase
3.6.1.31 phosphoribosyl-ATP diphosphatase
3.6.1.32 created 1984, deleted 2000
3.6.1.33 created 1984, deleted 2000
3.6.1.34 created 1984, deleted 2000
3.6.1.35 created 1984, deleted 2000
3.6.1.36 created 1984, deleted 2000
3.6.1.37 created 1984, deleted 2000
3.6.1.38 created 1984, deleted 2000
3.6.1.39 thymidine-triphosphatase
3.6.1.40 guanosine-5′-triphosphate,3′-diphosphate phosphatase
3.6.1.41 bis(5′-nucleosyl)-tetraphosphatase (symmetrical)
3.6.1.42 guanosine-diphosphatase
3.6.1.43 dolichyldiphosphatase
3.6.1.44 oligosaccharide-diphosphodolichol diphosphatase
3.6.1.45 UDP-sugar diphosphatase
3.6.1.46 created 2000, deleted 2003
3.6.1.47 created 2000, deleted 2003
3.6.1.48 created 2000, deleted 200
3.6.1.49 created 2000, deleted 2003
3.6.1.50 created 2000, deleted 2003
3.6.1.51 created 2000, deleted 2003
3.6.1.52 diphosphoinositol-polyphosphate diphosphatase
3.6.1.53 Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.56 2-hydroxy-dATP diphosphatase
3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose hydrolase
3.6.1.58 8-oxo-dGDP phosphatase
3.6.1.59 5′-(N7-methyl 5′-triphosphoguanosine)-[mRNA] diphosphatase
3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming)
3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming)
3.6.1.62 5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase
3.6.1.63 α-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
3.6.1.64 inosine diphosphate phosphatase
3.6.1.65 (d)CTP diphosphatase
3.6.1.66 XTP/dITP diphosphatase
3.6.1.67 dihydroneopterin triphosphate diphosphatase
3.6.1.68 geranyl diphosphate phosphohydrolase
3.6.1.69 8-oxo-(d)GTP phosphatase
3.6.1.70 guanosine-5′-diphospho-5′-[DNA] diphosphatase
3.6.1.71 adenosine-5′-diphospho-5′-[DNA] diphosphatase
3.6.1.72 DNA-3′-diphospho-5′-guanosine diphosphatase
3.6.1.73 inosine/xanthosine triphosphatase
3.6.1.74 mRNA 5′-phosphatase
3.6.1.75 diacylglycerol diphosphate phosphatase
3.6.2 In sulfonyl-containing anhydrides
3.6.3 Acting on acid anhydrides to catalyse transmembrane movement of substances
3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
3.6.5 Acting on GTP to facilitate cellular and subcellular movement
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
5.1 Racemases and epimerases
5.2 cis-trans-Isomerases
5.3 Intramolecular oxidoreductases
5.4 Intramolecular transferases
5.5 Intramolecular lyases
5.6 Isomerases altering macromolecular conformation
5.99 Other isomerases
6 Ligases
7 Translocases