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EC 2.1.3.15 Details
show Brenda entryEC number
2.1.3.15
Accepted name
acetyl-CoA carboxytransferase
Reaction
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
Other name(s)
accAD (gene names)
Systematic name
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine:acetyl-CoA:carboxytransferase
CAS registry number
9023-93-2
Comment
The enzyme catalyses the transfer of a carboxyl group carried on a biotinylated biotin carboxyl carrier protein (BCCP) to acetyl-CoA, forming malonyl-CoA. In some organisms this activity is part of a multi-domain polypeptide that includes the carrier protein and EC 6.3.4.14, biotin carboxylase (see EC 6.4.1.2, acetyl-CoA carboxylase). Some enzymes can also carboxylate propanonyl-CoA and butanoyl-CoA (cf. EC 6.4.1.3, propionyl-CoA carboxylase).
History
created 2017
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.13.12.10 created 1989, modified 1999, deleted 2001
