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EC 1.13.12.16 Details
show Brenda entryEC number
1.13.12.16
Accepted name
nitronate monooxygenase
Reaction
ethylnitronate + O2 = acetaldehyde + nitrite + other products
Other name(s)
NMO,
2-nitropropane dioxygenase (incorrect)
Systematic name
nitronate:oxygen 2-oxidoreductase (nitrite-forming)
Comment
Previously classified as 2-nitropropane dioxygenase (EC 1.13.11.32), but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Neither hydrogen peroxide nor superoxide were detected during enzyme turnover. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity.
History
created 1984 as EC 1.13.11.32, transferred 2009 to EC 1.13.12.16, modified 2011
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.13.12.10 created 1989, modified 1999, deleted 2001
