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EC 1.10.99.2 Details
show Brenda entryEC number
1.10.99.2
Accepted name
ribosyldihydronicotinamide dehydrogenase (quinone)
Reaction
1-(β-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(β-D-ribofuranosyl)nicotinamide + a hydroquinone
Other name(s)
NRH:quinone oxidoreductase 2,
NQO2,
NAD(P)H:quinone oxidoreductase-2 (misleading),
QR2,
quinone reductase 2,
N-ribosyldihydronicotinamide dehydrogenase (quinone),
NAD(P)H:quinone oxidoreductase2 (misleading)
Systematic name
1-(β-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase
CAS registry number
667919-86-0
Comment
A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the oestrogens 17β-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3].
History
created 2005, deleted 2014
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002
