EC Explorer

1.5.1.12

1-pyrroline-5-carboxylate dehydrogenase

L-glutamate γ-semialdehyde + NAD⁺ + H₂O = L-glutamate + NADH + H⁺

Δ¹-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD⁺ oxidoreductase, 1-pyrroline-5-carboxylate:NAD⁺ oxidoreductase, Δ¹-pyrroline-5-carboxylic acid dehydrogenase

L-glutamate γ-semialdehyde:NAD⁺ oxidoreductase

9054-82-4

This enzyme catalyses the irreversible oxidation of glutamate-γ-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.99.8, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate γ-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP⁺ can also act as acceptor, but with lower activity [5].

created 1972, modified 2008, deleted 2013