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EC 1.1.99.39 Details
EC number
1.1.99.39
Accepted name
D-2-hydroxyglutarate dehydrogenase
Reaction
(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor
Other name(s)
D2HGDH (gene name)
Systematic name
(R)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Comment
Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.
History
created 2013
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