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EC 1.21.4.5 Details
show Brenda entryEC number
1.21.4.5
Accepted name
tetrachlorohydroquinone reductive dehalogenase
Reaction
(1) 2,6-dichlorohydroquinone + Cl- + glutathione disulfide = 2,3,6-trichlorohydroquinone + 2 glutathione;;(2) 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione
Other name(s)
pcpC (gene name)
Systematic name
glutathione disulfide:2,6-dichlorohydroquinone (chlorinating)
Comment
The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, converts tetrachlorohydroquinone to 2,6-dichlorohydroquinone in two steps, via 2,3,6-trichlorohydroquinone, using glutathione as the reducing agent. The enzyme is sensitive to oxidation - when an internal L-cysteine residue is oxidized, the enzyme produces 2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone and 2,6-dichloro-3-(glutathion-S-yl)-hydroquinone instead of its normal products.
History
created 2018
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002 1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
