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EC 3.1.1.79 Details
EC number
3.1.1.79
Accepted name
hormone-sensitive lipase
Reaction
(1) diacylglycerol + H2O = monoacylglycerol + a carboxylate;;(2) triacylglycerol + H2O = diacylglycerol + a carboxylate;;(3) monoacylglycerol + H2O = glycerol + a carboxylate
Other name(s)
HSL
Systematic name
diacylglycerol acylhydrolase
Comment
This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) [2,3,4] as well as cholesteryl esters [2,4], steroid fatty acid esters [5], retinyl esters [6] and p-nitrophenyl esters [4,7]. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond [8]. The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
History
created 2004
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.1 carboxylesterase
3.1.1.2 arylesterase
3.1.1.3 triacylglycerol lipase
3.1.1.4 phospholipase A2
3.1.1.5 lysophospholipase
3.1.1.6 acetylesterase
3.1.1.7 acetylcholinesterase
3.1.1.8 cholinesterase
3.1.1.9 created 1961, deleted 1972
3.1.1.10 tropinesterase
3.1.1.11 pectinesterase
3.1.1.12 created 1961, deleted 1972
3.1.1.13 sterol esterase
3.1.1.14 chlorophyllase
3.1.1.15 L-arabinonolactonase
3.1.1.16 created 1961, deleted 1972
3.1.1.17 gluconolactonase
3.1.1.18 created 1961, deleted 1982
3.1.1.19 uronolactonase
3.1.1.20 tannase
3.1.1.21 retinyl-palmitate esterase
3.1.1.22 hydroxybutyrate-dimer hydrolase
3.1.1.23 acylglycerol lipase
3.1.1.24 3-oxoadipate enol-lactonase
3.1.1.25 1,4-lactonase
3.1.1.26 galactolipase
3.1.1.27 4-pyridoxolactonase
3.1.1.28 acylcarnitine hydrolase
3.1.1.29 aminoacyl-tRNA hydrolase
3.1.1.30 D-arabinonolactonase
3.1.1.31 6-phosphogluconolactonase
3.1.1.32 phospholipase A1
3.1.1.33 6-acetylglucose deacetylase
3.1.1.34 lipoprotein lipase
3.1.1.35 dihydrocoumarin hydrolase
3.1.1.36 limonin-D-ring-lactonase
3.1.1.37 steroid-lactonase
3.1.1.38 triacetate-lactonase
3.1.1.39 actinomycin lactonase
3.1.1.40 orsellinate-depside hydrolase
3.1.1.41 cephalosporin-C deacetylase
3.1.1.42 chlorogenate hydrolase
3.1.1.43 α-amino-acid esterase
3.1.1.44 4-methyloxaloacetate esterase
3.1.1.45 carboxymethylenebutenolidase
3.1.1.46 deoxylimonate A-ring-lactonase
3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase
3.1.1.48 fusarinine-C ornithinesterase
3.1.1.49 sinapine esterase
3.1.1.50 wax-ester hydrolase
3.1.1.51 phorbol-diester hydrolase
3.1.1.52 phosphatidylinositol deacylase
3.1.1.53 sialate O-acetylesterase
3.1.1.54 acetoxybutynylbithiophene deacetylase
3.1.1.55 acetylsalicylate deacetylase
3.1.1.56 methylumbelliferyl-acetate deacetylase
3.1.1.57 2-pyrone-4,6-dicarboxylate lactonase
3.1.1.58 N-acetylgalactosaminoglycan deacetylase
3.1.1.59 juvenile-hormone esterase
3.1.1.60 bis(2-ethylhexyl)phthalate esterase
3.1.1.61 protein-glutamate methylesterase
3.1.1.62 created 1989, deleted 1992
3.1.1.63 11-cis-retinyl-palmitate hydrolase
3.1.1.64 retinoid isomerohydrolase
3.1.1.65 L-rhamnono-1,4-lactonase
3.1.1.66 5-(3,4-diacetoxybut-1-ynyl)-2,2′-bithiophene deacetylase
3.1.1.67 fatty-acyl-ethyl-ester synthase
3.1.1.68 xylono-1,4-lactonase
3.1.1.69 created 1992, deleted 2002
3.1.1.70 cetraxate benzylesterase
3.1.1.71 acetylalkylglycerol acetylhydrolase
3.1.1.72 acetylxylan esterase
3.1.1.73 feruloyl esterase
3.1.1.74 cutinase
3.1.1.75 poly(3-hydroxybutyrate) depolymerase
3.1.1.76 poly(3-hydroxyoctanoate) depolymerase
3.1.1.77 acyloxyacyl hydrolase
3.1.1.78 polyneuridine-aldehyde esterase
3.1.1.79 hormone-sensitive lipase
3.1.1.80 acetylajmaline esterase
3.1.1.81 quorum-quenching N-acyl-homoserine lactonase
3.1.1.82 pheophorbidase
3.1.1.83 monoterpene ε-lactone hydrolase
3.1.1.84 cocaine esterase
3.1.1.85 pimelyl-[acyl-carrier protein] methyl ester esterase
3.1.1.86 rhamnogalacturonan acetylesterase
3.1.1.87 fumonisin B1 esterase
3.1.1.88 pyrethroid hydrolase
3.1.1.89 protein phosphatase methylesterase-1
3.1.1.90 all-trans-retinyl ester 13-cis isomerohydrolase
3.1.1.91 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase
3.1.1.92 4-sulfomuconolactone hydrolase
3.1.1.93 mycophenolic acid acyl-glucuronide esterase
3.1.1.94 versiconal hemiacetal acetate esterase
3.1.1.95 aclacinomycin methylesterase
3.1.1.96 D-aminoacyl-tRNA deacylase
3.1.1.97 methylated diphthine methylhydrolase
3.1.1.98 [Wnt protein] O-palmitoleoyl-L-serine hydrolase
3.1.1.99 6-deoxy-6-sulfogluconolactonase
3.1.1.100 chlorophyllide a hydrolase
3.1.1.101 poly(ethylene terephthalate) hydrolase
3.1.1.102 mono(ethylene terephthalate) hydrolase
3.1.1.103 teichoic acid D-alanine hydrolase
3.1.1.104 5-phospho-D-xylono-1,4-lactonase
3.1.1.105 3-O-acetylpapaveroxine carboxylesterase
3.1.1.106 O-acetyl-ADP-ribose deacetylase
3.1.1.107 apo-salmochelin esterase
3.1.1.108 iron(III)-enterobactin esterase
3.1.1.109 iron(III)-salmochelin esterase
3.1.1.110 xylono-1,5-lactonase
3.1.1.111 phosphatidylserine sn-1 acylhydrolase
3.1.1.112 isoamyl acetate esterase
3.1.1.113 ethyl acetate hydrolase
3.1.1.114 methyl acetate hydrolase
3.1.1.115 D-apionolactonase
3.1.1.116 sn-1-specific diacylglycerol lipase
3.1.1.117 (4-O-methyl)-D-glucuronate—lignin esterase
3.1.1.118 phospholipid sn-1 acylhydrolase
3.1.1.119 exo-acting protein-α-N-acetylgalactosaminidase
3.1.2 Thioester hydrolases
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.3 succinyl-CoA hydrolase
3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase
3.1.2.5 hydroxymethylglutaryl-CoA hydrolase
3.1.2.6 hydroxyacylglutathione hydrolase
3.1.2.7 glutathione thiolesterase
3.1.2.8 created 1961, deleted 1978
3.1.2.9 created 1961, deleted 1964
3.1.2.10 formyl-CoA hydrolase
3.1.2.11 acetoacetyl-CoA hydrolase
3.1.2.12 S-formylglutathione hydrolase
3.1.2.13 S-succinylglutathione hydrolase
3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase
3.1.2.15 ubiquitin thiolesterase
3.1.2.16 citrate-lyase deacetylase
3.1.2.17 (S)-methylmalonyl-CoA hydrolase
3.1.2.18 ADP-dependent short-chain-acyl-CoA hydrolase
3.1.2.19 ADP-dependent medium-chain-acyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.21 dodecanoyl-[acyl-carrier-protein] hydrolase
3.1.2.22 palmitoyl[protein] hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase
3.1.2.24 created 2000, deleted 2005
3.1.2.25 phenylacetyl-CoA hydrolase
3.1.2.26 bile-acid-CoA hydrolase
3.1.2.27 choloyl-CoA hydrolase
3.1.2.28 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
3.1.2.29 fluoroacetyl-CoA thioesterase
3.1.2.30 (3S)-malyl-CoA thioesterase
3.1.2.31 dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
3.1.2.32 2-aminobenzoylacetyl-CoA thioesterase
3.1.3 Phosphoric-monoester hydrolases
3.1.4 Phosphoric-diester hydrolases
3.1.5 Triphosphoric-monoester hydrolases
3.1.6 Sulfuric-ester hydrolases
3.1.7 Diphosphoric-monoester hydrolases
3.1.8 Phosphoric-triester hydrolases
3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters
3.1.12 Exodeoxyribonucleases producing 3′-phosphomonoesters
3.1.13 Exoribonucleases producing 5′-phosphomonoesters
3.1.14 Exoribonucleases producing 3'-phosphomonoesters
3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters
3.1.23 Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass)
3.1.24 Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass)
3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases
3.1.26 Endoribonucleases producing 5'-phosphomonoesters
3.1.27 Endoribonucleases producing 3'-phosphomonoesters
3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases