3.4.14.1: dipeptidyl-peptidase I

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase I, go to the full flat file.

Reaction

Release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro =

Synonyms

Cat C, CATC, cathepsin C, cathepsin J, CTSC, DAP I, DDPI, dipeptide arylamidase I, dipeptidyl aminopeptidase I, dipeptidyl peptidase I, dipeptidyl peptidase I/cathepsin C, dipeptidyl transferase, DPAP1, DPAP2, DPP I, DPP-I, DPPI, EC 3.4.4.9, hDPPI, PBANKA_146070, PFL2290w

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

                3.4.14.1 dipeptidyl-peptidase I

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Results	in table
13	Activating Compound
958	AA Sequence
9	Application
1	CAS Registry Number
11	Cloned(Commentary)
2	Crystallization (Commentary)
535	Disease/ Diagnostics
2	Expression
10	General Information
1	General Stability
64	IC50 Value
129	Inhibitors
12	kcat/KM [mM/s]
12	Ki Value [mM]
34	KM Value [mM]
21	Localization
18	Metals/Ions
14	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
90	Organism
72	PDB ID
14	pH Optimum
5	pH Range
5	pH Stability
1	pI Value
5	Posttranslational Modification
2	Protein Variants
16	Purification (Commentary)
1	Reaction
4	Reaction Type
90	Reference
100	Source Tissue
6	Specific Activity [micromol/min/mg]
2	Storage Stability
155	Substrates and Products (Substrate)
5	Subunits
65	Synonyms
3	Temperature Optimum [°C]
4	Temperature Stability [°C]
24	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.14.1 - dipeptidyl-peptidase I

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

molecular modeling of inhibitor docking. Esters of dehydropeptides containing C-terminal (Z)-dehydrophenylalanine and dehydroalanine appear to be moderate or weak inhibitors of cathepsin C, with some of them exhibiting slow-binding behavior. They are rather bind at the surface of the enzyme and are not submersed in its binding cavities

Bos taurus

Q3ZCJ8

754604

molecular docking of substrate beta-(2-thienyl)Ala-beta-(7-methoxycoumarin-4-yl)Ala-Ser-Gly-Tyr(3-NO2). The interactions between the amino-terminal group of the substrate and the Asp1 and Gly277 of Cat C are responsible for the substrate N-terminus docking and are crucial for proteolytic activity

Homo sapiens

P53634

752592