2.6.1.38: histidine transaminase
This is an abbreviated version!
For detailed information about histidine transaminase, go to the full flat file.
Reaction
Synonyms
Hat-1, HISAT, HisC, histidine aminotransferase, histidine transaminase, histidine-2-oxoglutarate aminotransferase, More, TTE2137
ECTree
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Substrates Products
Substrates Products on EC 2.6.1.38 - histidine transaminase
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REACTION DIAGRAM
histidine + 2-oxocaproate
imidazol-5-yl-pyruvate + L-norleucine
-
-
-
-
r
histidine + 2-oxoglutarate
imidazol-5-yl-pyruvate + L-glutamate
-
-
-
-
r
L-histidine + 2-oxobutyrate
imidazol-5-yl-pyruvate + 2-aminobutanoate
-
-
-
-
r
L-histidine + pyruvate
imidazol-5-yl-pyruvate + L-alanine
-
ping pong reaction mechanism
-
-
r
L-histidine + 2-oxoglutarate
-
-
-
-
r
(imidazol-5-yl)pyruvate + L-glutamate
L-histidine + 2-oxoglutarate
-
-
-
-
r
histidine + 2-oxoglutarate
-
essential for utilization of imidazolyl-L-lactate as sole carbon source
-
r
imidazol-5-yl-pyruvate + L-glutamate
histidine + 2-oxoglutarate
-
essential for utilization of imidazolyl-L-lactate as sole carbon source
-
r
imidazol-5-yl-pyruvate + L-glutamate
histidine + 2-oxoglutarate
-
-
-
r
imidazol-5-yl-pyruvate + L-glutamate
histidine + 2-oxoglutarate
-
involved in nikkomycin biosynthesis, essential in the utilization of imidazol-L-lactate and imidazole pyruvate as carbon sources
-
-
r
L-histidine + 2-oxoglutarate
-
reaction mechanism ping pong, great specificity for histidine as amino donor, highly specific for 2-oxoglutarate in the reverse reaction, very slight activity with 2-oxomalonate or 4-methyl-2-oxopentanoate, L-tyrosine, phenylalanine or L-tryptophan
-
r
imidazol-5-yl-pyruvate + L-glutamate
L-histidine + 2-oxoglutarate
-
reaction mechanism ping pong, great specificity for histidine as amino donor, highly specific for 2-oxoglutarate in the reverse reaction, very slight activity with 2-oxomalonate or 4-methyl-2-oxopentanoate, L-tyrosine, phenylalanine or L-tryptophan
-
r
imidazol-5-yl-pyruvate + L-glutamate
L-histidine + 2-oxoglutarate
-
-
-
r
imidazol-5-yl-pyruvate + L-glutamate
L-histidine + 2-oxoglutarate
-
-
-
-
r
?
-
-
L-histidinol phosphate, D-histidine, 5'-N-methyl-L-histidine and pyruvate are no substrates
-
-
?
additional information
?
-
-
L-histidinol phosphate, D-histidine, 5'-N-methyl-L-histidine and pyruvate are no substrates
-
-
?
additional information
?
-
-
no activity observed if L-alanine or L-aspartate replaces glutamate, no activity observed if 2-oxoglutarate is replaced by glyoxylate, pyruvate, 2-oxobutyrate or 2-oxoisocaproate
-
-
?
additional information
?
-
-
does not use aromatic amino acids as amino substrates, L-phenylalanine, L-tyrosine, L-tryptophan and D-histidine are no substrates, does not react with L-histidinol phosphate, no activity on gels towards L-alanine, L-leucine, L-lysine, L-glutamate and L-aspartate with pyruvate as amino acceptor, no activity towards L-aspartate with 2-oxoglutarate
-
-
?