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2.6.1.3: cysteine transaminase

This is an abbreviated version!
For detailed information about cysteine transaminase, go to the full flat file.

Word Map on EC 2.6.1.3

Reaction

L-cysteine
+
2-oxoglutarate
=
Mercaptopyruvate
 +
L-glutamate

Synonyms

aminotransferase, cysteine, CGT, cysteine aminotransferase, L-cysteine aminotransferase, L-cysteine-2-oxoglutarate aminotransferase, More

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.3 cysteine transaminase

General Information

General Information on EC 2.6.1.3 - cysteine transaminase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
cystathionine beta-synthase, cysteine aminotransferase, and mercaptopyruvate sulfurtransferase, but not cystathionine gamma-lyase, are expressed in PC12 cells and the dorsal root ganglion, and appreciable amounts of H2S are produced from L-cysteine in the presence of alpha-ketoglutarate, together with dithiothreitol. The production of H2S is inhibited by cysteine aminotransferase inhibitor aminooxyacetic acid, and competitive cysteine aminotransferase substrates L-aspartate and oxaloacetate. The amount of H2S produced by cysteine aminotransferase/mercaptopyruvate sulfurtransferase at pH 8.0, a physiological mitochondrial matrix pH, is comparable to that produced by cystathionine beta-synthase and cystathionine beta-synthase in the liver and the brain, respectively