2.4.1.229: [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase
This is an abbreviated version!
For detailed information about [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase, go to the full flat file.
Reaction
Synonyms
acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycoprotein serine/threonine, acetylglucosaminyltransferase, uridine diphosphoacetylglucose-protein Skp1 hydroxyproline, Dd-ppGnT1, GnT1, GnT51, hydroxyproline-capping enzyme, Skp1 alpha-GlcNAcT1, Skp1 alpha-GlcNAcT1-like enzyme, Skp1-HyPro GlcNAc-transferase, UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase, UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase, UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase
ECTree
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Reaction
Reaction on EC 2.4.1.229 - [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase
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UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L-proline = UDP + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline
UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L-proline = UDP + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline
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UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L-proline = UDP + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline
Requires dithiothreitol and a divalent cation for activity. This enzyme commences the building up of a pentasaccharide (Galalpha1-6Galalpha1-L-Fucalpha1-2Galbeta1-3GlcNAc) on Hyp-143 of the Dictyostelium protein Skp1, which is required for the ubiquitination of cell-cycle regulatory proteins and transcription factors. The fucose residue is probably in the alpha configuration. The specificity of the enzyme for Skp1-Hyp-143 and its high affinity for this substrate suggests that it is the GlcNAc-transferase that modifies Skp1 in vivo
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