2.3.1.284: 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
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For detailed information about 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase, go to the full flat file.
Reaction
3 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose = + 2 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose
Synonyms
chp1, Chp2, diacyltrehalose acyltransferase, rv3822, SL1278 acyltransferase Chp1
ECTree
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General Information
General Information on EC 2.3.1.284 - 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
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physiological function
acyltransferase Chp1 accepts a diacyl sulfolipid and transfers an acyl group regioselectively from one donor substrate molecule to a second acceptor molecule in two successive reactions to yield a tetraacylated product. Chp1 is fully active in vitro, but in Mycobacterium tuberculosis, its function is potentiated by sulfolipid transporter MmpL8
physiological function
Chp2 is essential for the final steps of polyacyltrehalose biosynthesis. Disruption of Chp2 leads to the loss of polyacyltrehalose and accumulation of tetraacyltrehalose as well as the accumulation of diacyltrehalose, implicating Chp2 as an acyltransferase acting downstream of PapA3. Chp2 activity is probably potentiated by the DAT/PAT transporter MmpL10
physiological function
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acyltransferase Chp1 accepts a diacyl sulfolipid and transfers an acyl group regioselectively from one donor substrate molecule to a second acceptor molecule in two successive reactions to yield a tetraacylated product. Chp1 is fully active in vitro, but in Mycobacterium tuberculosis, its function is potentiated by sulfolipid transporter MmpL8
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physiological function
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Chp2 is essential for the final steps of polyacyltrehalose biosynthesis. Disruption of Chp2 leads to the loss of polyacyltrehalose and accumulation of tetraacyltrehalose as well as the accumulation of diacyltrehalose, implicating Chp2 as an acyltransferase acting downstream of PapA3. Chp2 activity is probably potentiated by the DAT/PAT transporter MmpL10
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