2.1.1.222: 2-polyprenyl-6-hydroxyphenol methylase
This is an abbreviated version!
For detailed information about 2-polyprenyl-6-hydroxyphenol methylase, go to the full flat file.
Reaction
Synonyms
2-polyprenyl-6-hydroxyphenyl methylase, 3-demethyl ubiquinone-9 3-methyltransferase, UbiG, UbiG methyltransferase, ubiquinone biosynthesis O-methyltransferase
ECTree
2.1.1.222 2-polyprenyl-6-hydroxyphenol methylaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.222 - 2-polyprenyl-6-hydroxyphenol methylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 2-(all-trans-decaprenyl)-5-hydroxy-6-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione
S-adenosyl-L-homocysteine + 2-(all-trans-decaprenyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
-
-
-
?
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-(farnesyl)phenol
i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli
i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol
-
?
S-adenosyl-L-methionine + 3-(all-trans-decaprenyl)-benzene-1,2-diol
S-adenosyl-L-homocysteine + 3-(all-trans-decaprenyl)-1-methoxybenzene-2-ol
-
-
-
?
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol
-
-
-
?
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol
-
i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol
i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol
-
?
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol
i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-all-trans-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli
i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol
-
?
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol
i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli
i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol
-
?
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
-
-
-
-
?
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
-
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3-(all-trans-octaprenyl)benzene-1,2-diol and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64)
-
-
?
additional information
?
-
the enzyme is involved in biosynthesis of ubiquinone-10 in human and catalyzes the methylation of 3-demethylubiquinol-10 to ubiquinol-10 (EC 2.1.1.64) and the methylation of 3,4-dihydroxy-5-decaprenylbenzoate to 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate (EC 2.1.1.114)
-
-
?
additional information
?
-
wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid (this activity is classified as EC 2.1.1.114) and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol
-
-
?
additional information
?
-
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-9 in Rattus norvegicus, 1. the methylation of 3,4-dihydroxy-5-nonaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-9 (this reaction is classified as EC 2.1.1.64)
-
-
?
additional information
?
-
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae, 1. the methylation of 3,4-dihydroxy-5-hexaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-6 (this reaction is classified as EC 2.1.1.64)
-
-
?
