1.5.1.53: methylenetetrahydrofolate reductase (NADPH)

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For detailed information about methylenetetrahydrofolate reductase (NADPH), go to the full flat file.

Reaction

Synonyms

5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, MET13, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH2), methylenetetrahydrofolic acid reductase, MTHFR, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.53 methylenetetrahydrofolate reductase (NADPH)

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Results	in table
3	AA Sequence
3	Application
1	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
4	General Information
1	General Stability
20	Inhibitors
5	Ki Value [mM]
28	KM Value [mM]
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
15	Organism
4	Pathway
3	pH Optimum
1	Posttranslational Modification
3	Protein Variants
5	Purification (Commentary)
1	Reaction
15	Reference
11	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
28	Substrates and Products (Substrate)
3	Subunits
17	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Stability [°C]
4	Turnover Number [1/s]

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Application on EC 1.5.1.53 - methylenetetrahydrofolate reductase (NADPH)

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Rattus norvegicus

D4A7E8

sensitive radioenzymatic assay that measures directly the reductive catalysis of N ,N -methylenetetrahydrofolate. The radio-labeled substrate, [ C14]N ,N -methyl enetetrahydrofolate, is prepared by condensation of [C14]formaldehyde with tetrahydrofolate. Its stability is maintained for several months by storage at -80°C in a pH 9.5 buffer

761407

medicine

2 entries

medicine

Homo sapiens

-

patients with severe methylenetetrahydrofolate reductase deficiency show neurologic disorders, mental retardation, and rapid deterioration

760537

medicine

Homo sapiens

P42898

testing of 478 individuals with myelomeningocele for attention-deficit hyperactivity disorder (ADHD) behavior plus genotyping for seven single nucleotide polymorphisms in the MTHFR gene. 28.7% of myelomeningocele participants exhibit rating scale elevations consistent with ADHD, of these 70.1% have scores consistent with the predominantly inattentive subtype. There is a positive association between the SNP rs4846049 in the 39-untranslated region of the MTHFR gene and the attention-deficit hyperactivity disorder phenotype in myelomeningocele participants

762250